Ernexa Therapeutics Set to Showcase Breakthrough Cancer Research

Breakthrough Data from Ernexa Therapeutics

CAMBRIDGE, Mass. – Ernexa Therapeutics (Nasdaq: ERNA) is set to present exciting new findings at the American Society of Clinical Oncology (ASCO) Annual Meeting 2025, taking place on June 2 in Chicago. This innovative company is at the forefront of developing cutting-edge cell therapies designed specifically for advanced cancer and autoimmune diseases.

Innovative iMSC Technology

The upcoming presentation will shed light on the technologically advanced induced mesenchymal stem cell (iMSC) platform developed by Ernexa. This platform utilizes iMSCs that are engineered to secrete essential cytokines, IL-7 and IL-15, directly into ovarian tumors. The significance of this technology lies in its ability to convert tumors previously classified as immunologically “cold” into “hot” tumors, effectively kickstarting a robust immune response.

Mechanism of Action

Derived from adult skin cells, these distinctive iMSCs are capable of migrating safely into the tumor microenvironment and promoting significant immune activation. According to researchers, this immune response includes enhanced infiltration of T cells and macrophages, key players in the immune system that are crucial in targeting cancer cells.

Successful Preclinical Results

In preclinical studies using a syngeneic ovarian cancer mouse model, the application of IL-7/IL-15-secreting iMSCs led to remarkable results. The treatment not only reduced tumor burden significantly but also extended the survival of the subjects involved in the study. This vital research is being conducted under the leadership of Dr. Michael Andreeff from The University of Texas MD Anderson Cancer Center.

A Vision for the Future

Sanjeev Luther, the President and CEO of Ernexa Therapeutics, enthusiastically commented on the recent developments, describing the research as a potential game changer in the fight against cancer. “Our mission is to tackle the challenge posed by immunologically ‘cold’ tumors, providing patients with innovative possibilities that previously appeared out of reach,” Luther stated. He emphasized that this breakthrough not only validates the iMSC platform but also signifies a critical stride toward developing more scalable and effective cell therapies.

Poster Presentation Details

During the ASCO conference, attendees can look forward to engaging with the Ernexa team at a dedicated poster presentation session. The details for this session are as follows:

• Date and Time: Monday, June 2 from 1:30 PM – 4:30 PM CDT
• Location: Hall A - Posters and Exhibits
• Poster Title: Engineering iPSC-derived mesenchymal stem cells (i MSCs) to secrete IL-7/IL-15 for modulation of the tumor microenvironment in a "cold" ovarian tumor model
• Track: Developmental Therapeutics—Immunotherapy
• Sub Track: Cellular Immunotherapy
• Abstract Number: 2538
• Poster Board Number: 185

About Ernexa Therapeutics

Ernexa Therapeutics is swiftly making a name for itself in the cellular therapy realm, with a particular focus on advanced solid tumors and autoimmune conditions. Their pioneering technology is centered around engineering induced pluripotent stem cells (iPSCs) into induced mesenchymal stem cells (iMSCs). The company's synthetic iMSCs promise a scalable and off-the-shelf treatment option, eliminating the need for patient-specific cell harvesting.

Current Projects

Ernexa is rigorously working on two promising cell therapy products currently in preclinical stages. The lead product, ERNA-101, aims to bolster the immune system's capabilities to identify and combat cancer cells. Simultaneously, ERNA-102 is in development to address inflammation and provide treatment for autoimmune diseases. The current focus remains firmly on ERNA-101 as a potential therapeutic option for ovarian cancer.

Connect with Ernexa Therapeutics

For those interested in learning more about Ernexa Therapeutics and their innovative approaches to oncology, further information is readily available on their official website.

Frequently Asked Questions

What is Ernexa Therapeutics focused on?

Ernexa Therapeutics focuses on developing innovative cell therapies to treat advanced cancer and autoimmune diseases.

What technology does Ernexa use?

They use induced mesenchymal stem cells (iMSCs) engineered to secrete cytokines for enhanced immune response in tumors.

What are the potential benefits of their therapies?

Their therapies aim to convert “cold” tumors into “hot” ones, enhancing the immune response and improving treatment outcomes.

Where will the new data be presented?

The new data will be presented at the ASCO Annual Meeting in Chicago, on June 2, 2025.

Who can attendees meet at the conference?

Conference attendees will have the opportunity to meet with Ernexa's Chief Scientific Officer, Robert Pierce, and discuss the innovative research.

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